Dengue fever, epidemiology, outbreak, china multilingual abstracts please see additional file 1 for translations of the abstract into the five official working languages of the united nations. Learn more about dengue fever causes, sign and symptoms, treatment and diagnosis at findatopdoc. Transmission occurs through the bite of infected aedes mosquitoes, principally aedes aegypti, which is also the principal urban vector of yellow fever. Facts about dengue fever talk about a disease caused by dengue virus of a mosquito. Caring for a child or family member sick with dengue.
This site is like a library, use search box in the widget to get ebook that you want. Our primary outcomes were a prevalence of laboratory. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. The ideal test for early diagnosis of dengue infection j vector borne dis 53, march 2016, pp. Dengue fever, dengue haemorrhagic fever and dengue shock syndrome are distinct clinical forms of an infection that is caused by dengue virus, a member of the flaviviridae family. Dengue virus is prevalent throughout the tropics and subtropics. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes lymphadenopathy, and rash. Dengue fever df is caused by an arbovirus and spread by aedes mosquitoes. We undertook a clinical study at the national paediatric hospital in phnom penh to evaluate clinical diagnostic parameters for dengue and predictors of disease outcome.
May 03, 2019 dengue fever presents in a nonspecific manner and may not be distinguishable from other viral or bacterial illness. Caring for a child or family member sick with dengue dengue. The global incidence of dengue has grown dramatically in recent decades. Dengue hemorrhagic fever is defined as acute onset of fever with nonspecific symptoms. Every year there are outbreaks of the disease in parts of north queensland. Febrile phase critical phase convalescent phase 25. Dengue is a febrile illness caused by infection with one of four dengue viruses denv transmitted by aedes aegypti or aedes albopictus mosquitoes during the taking of a blood meal.
Clinical presentation can range from a mild fever to classical dengue fever with hemorrhage dhf andor shock dengue shock syndrome dss. The queensland dengue management plan is issued under the authority of the queensland chief health officer. Clinical and serologic study of cuban children with dengue hemorrhagic feverdengue shock syndrome dhfdss. Dengue hemorrhagic fever is an acute infectious disease caused by dengue virus. If you become sick after traveling to a tropical area, let. For a typical dengue fever, the treatment is purely concerned with the relief of symptoms. Onset of symptoms is characterized by a biphasic, highgrade fever lasting for 3 days to 1 week. It is an important cause of fever in the returned traveller. This is followed by hemorrhagic manifestations that may include a positive tourniquet test andor minor or major bleeding phenomena, thrombocytopenia less than or equal to 100,000mm 3, and hemoconcentration hematocrit increased by greater than or equal to 20%, or other objective evidence. Dengue is a disease caused by the bite of a mosquito infected with any one of four specific dengue viruses.
Dengue fever dengue virus types 1 4 flavivirus none high 1. Febrile phase the onset of dengue fever is usually with sudden rise in temperature which may be biphasic, lasting 58 days and commonly associated with. Some infections result in dengue haemorrhagic fever dhf. The classification of severe dengue has been complicated by the variation in clinical picture, for which the. Some symptoms of dengue fever include joint pain, muscle paint, vomiting, headache, rack and high fever. May 03, 2019 the epidemiology of dengue fever in africa is more poorly characterized. Laboratory diagnosis of suspected dengue specimens involves using serological tests starting five days after illness onset to measure antibody response. The term incidence of dengue fever refers to the annual diagnosis rate, or the number of new cases of dengue fever diagnosed each year. Dengue fever is caused by virus spread by aedes egypti mosquitoes. To meet the challenge of preventing or minimising dengue outbreaks in queensland, queensland health in collaboration with local government and other key stakeholders have developed the queensland dengue management plan 20152020 dmp.
Dengue fever symptoms, causes, contagious, rash, prevention. Dengue virus infection is spread primarily by the mosquito vector aedes aegypti and causes significant morbidity and mortality worldwide. Zika, chikungunya, and dengue virus infections should all be considered for patients with acute fever, rash, myalgia, or arthralgia who have traveled within the previous 2 weeks to an area with ongoing transmission or are living in an area with ongoing transmission. Dengue is endemic throughout cambodia, a country faced with significant health and economic challenges. About 1 in 20 people with dengue will develop severe dengue. Listing a study does not mean it has been evaluated by the u. The mosquitos that carry this disease are mainly in tropical areas so travelers may arrive in the. Because dengue fever is spread by a virus, there is no specific medicine or antibiotic to treat it. There is no treatment for dengue fever, and about 40 percent of the worlds population is at risk. Mar 02, 2020 dengue is a mosquitoborne viral infection. This is followed by hemorrhagic manifestations that may include a positive tourniquet test andor minor or major bleeding phenomena, thrombocytopenia less than or equal to 100,000mm 3, and hemoconcentration hematocrit increased by greater than or equal to 20%, or other objective evidence of. Dengue fever is a disease caused by a family of viruses transmitted by aedes mosquitoes symptoms of dengue fever include severe joint and muscle pain, swollen lymph nodes, headache, fever, exhaustion, and rash. The histology was done in tissue sections stained with hematoxylin and eosin.
Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of. Be sure to describe international trips in detail, including the countries you visited and the dates. According to the pan american health organization paho, the clinical description of dengue fever is an acute febrile illness of 27 days duration associated with 2 or more of the following. Dengue fever is a mosquitotransmitted virus that occurs in the tropics or subtropics. Mind it, there is no vaccine available for the treatment of dengue fever currently. In a 1993 epidemic in the comoros, an estimated 60,000 persons were infected with dengue.
The presence of fever, rash, and headache the dengue triad is characteristic of dengue fever. It is also known as breakbone fever, since it can be extremely painful. Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. Nov 02, 2018 dengue fever is a mosquitoborne infection that causes severe flulike symptoms and can be fatal. Description of the clinical picture of dengue hemorrhagic feverdengue shock syndrome dhfdss in adults. Characterizing a large outbreak of dengue fever in. It can be lifethreatening, and are caused by four closely related virus serotypes of the genus flavivirus, family flaviviridae. Severe dengue requires hospitalization and can be life threatening. Dengue is the most common and important arthropodborne viral arboviral illness in humans. Although the fever has gone away, the next phase of dengue can be dangerous for some people. Once you are infected with one of the dengue viruses, you will develop immunity to that.
Dengue chapter 4 2020 yellow book travelers health. Mar 12, 2020 dengue is an infection caused by a virus. Read more information on homeopathic remedies, risks, and prevention. Laboratory confirmation can be made from a single acutephase serum specimen obtained early. Doctors can diagnose dengue infection with a blood test to check for the virus or antibodies to it. Clinical and laboratory diagnosis of dengue virus infection.
Dengue typically has an incubation period of 47 d, although symptom onset can occur up to 14 d after infection. After a person is infected by the virus, the symptoms will begin from 3 to 14 days. Histopathological diagnosis of myocarditis in a dengue. Dynamic dengue haemorrhagic fever calculators as clinical. Dengue fever is a mosquitoborne tropical disease caused by the dengue virus. Isolation of dengue virus from or demonstration of specific arboviral antigen or genomic sequences in tissue, blood, cerebrospinal fluid csf, or other body fluid by polymerase chain reaction pcr test, immunofluorescence or immunohistochemistry, or. Jul 24, 2009 diagnosis and characterization of dengue fever in children the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Early diagnosis of dengue disease severity in a resource.
Dengue has become a widespread infection over the past few year, extending from endemic to nonendemic areas. Dengue and dengue hemorrhagic fever pubmed central pmc. Symptoms typically begin three to fourteen days after infection. Naats should be performed on serum specimens collected 7 days or less after symptom onset. Since the second edition of dengue haemorrhagic fever. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, and the following warning signs. Dengue fever, dengue haemorrhagic fever, laboratory diagnosis, sri lanka introduction dengue fever df is an arthropod borne virus infection caused by dengue viruses denv. Jan 27, 2016 introduction dengue and dengue hemorrhagic fever dhf result from infection by any of four serotypes of dengue viruses. Dengue fever is a disease caused by a family of viruses transmitted by infected mosquitoes. Classical dengue fever is an acute infection presenting clinically 410 days following the bite of an infected mosquito. Infection may be asymptomatic or present with a broad range of clinical manifestations including a mild febrile illness to a lifethreatening shock syndrome. How does your doctor or other healthcare provider determine if you have contracted dengue fever. The incidence of dengue has increased dramatically in recent decades, with estimates of 40%50% of the worlds population at risk for the. Symptoms include fever, headache, muscle and joint pains, and a.
Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. Background dengue is an arthropodborne viral disease caused. Dengue fever is present in 19 countries on the african continent. For patients with suspected dengue virus disease, naats are the preferred method of laboratory diagnosis. Pulmonary hemorrhage syndrome associated with dengue fever. Diagnosing dengue fever can be difficult, because its signs and symptoms can be easily confused with those of other diseases such as malaria, leptospirosis and typhoid fever. Other diseases caused by flaviviruses include yellow fever, japanese encephalitis and murray valley encephalitis. Definition dengue virus infections cause a spectrum of illness ranging from asymptomatic, mild undifferentiated fever to classical dengue fever df, and dengue fever with haemorrhagic manifestations, or dengue haemorrhagic fever dhf and the dengue shock syndrome dss. Severe dengue infection can lead to death, therefore, clinicians should should aim for. Natural course the clinical course of illness passes through 3 phases. There are four types of denv serotypes denv1, denv2, denv3 and denv4, meaning that it is possible to be infected four times. Health experts have known about dengue fever for more than 200 years. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock. Dengue and severe dengue world health organization.
Clinicians should consider dengue in a patient who was in an endemic area within 2 weeks of symptom onset. Dengue is an acute viral illness caused by rna virus of the family flaviviridae and spread by aedes mosquitoes. Dengue fever is a mosquitoborne infection that causes severe flulike symptoms and can be fatal. Your doctor will likely ask about your medical and travel history. A cuteonset high fever, muscle and joint pain, myalgia, cutaneous rash. Symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. Clinical manifestations of dengue and dengue hemorrhagic fever undifferentiated fever classic dengue fever dengue hemorrhagic fever dengue shock syndrome 14. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever vii dengue fever is the fastest emerging arboviral infection spread by aedes mosquitoes with major public health consequences in over 100 tropical and subtropical countries in southeast asia, the western pacific and south and central america. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking. Dengue chapter 4 2020 yellow book travelers health cdc. Apr 27, 2020 dengue fever is a common tropical infection. It is transmitted by mosquitoes of the genus aedes, which are widely distributed in subtropical and tropical areas of the world see the image below. According to the pan american health organization paho, the clinical description of dengue fever is an acute febrile illness of 27 days duration associated with 2. Clinical diagnosis what to look for when you evaluate patients for dhf how to treat dengue fever clinical management laboratory diagnosis epidemiology dengue is a mosquitoborne disease caused by any one of four closely related dengue viruses denv1, 2, 3, and 4.
The prevention of dengue fever download ebook pdf, epub. Primers for dengue virus strains based on their sequence. This page presents a variety of statistics about dengue fever. Df follows both primary and secondary infections, and is most frequently encountered in adults and older children. Highresolution ct demonstrated bilateral areas of consolidation with air bronchogram and ground glass opacities, as well as small bilateral. Symptoms of dengue fever infection usually begin 47 days after the infectious mosquito bite and typically last 310 days. Aedes aegypti is present in a large portion of the middle east and subsaharan africa. It causes high fever, severe headache, pain behind the eye, joint pain, and muscle pain. The virus responsible for causing dengue, is called dengue virus denv. The clinical diagnosis of myocarditis was considered in 4527% patients. Dengue fever, also known as breakbone fever, is a mosquitoborne infectious tropical disease caused by the dengue virus. Diagnosis and characterization of dengue fever in children.
Multivariate logistic regression analysis was performed. Dengue is an infection caused by one of four dengue viruses in the family flaviviridae. Dengue fever is a disease spread by the aedes aegypti mosquito and is caused by one of four dengue viruses. Of them, 149 patients 90% had secondary dengue infection and in 5 patients, den1 was identified as the causative serotype. The term prevalence of dengue fever usually refers to the estimated population of people who are managing dengue fever at any given time.
Racgp dengue clinical and public health ramifications. This increase is believed to be to be due to multiple factors. Because dengue is a nationally notifiable disease, all suspected cases should be reported to the state or local health department. Click download or read online button to get the prevention of dengue fever book now. Comparative evaluation of validity and costbenefit. Dengue is a self limiting acute mosquito transmitted disease characterized by fever, headache, muscle, joint pains, rash, nausea and vomiting. Dengue fever frequently asked questions faq general questions. In terms of morbidity, mortality and economic costs, dengue is. We described the highresolution ct findings in a 70yearold male with the disease, which was diagnosed by clinical examination and confirmed by serological methods.
Warning signs generally begin in the 2448 hours after the fever has gone away. Dengue fever presents in a nonspecific manner and may not be distinguishable from other viral or bacterial illness. Feb 16, 2018 diagnosing dengue fever can be difficult, because its signs and symptoms can be easily confused with those of other diseases such as malaria, leptospirosis and typhoid fever. Mantelhaenszel test were used for the comparisons of proportions fishers exact test if a cell had an expected frequency below five. Defi niti on dengue fever and dengue hemorrhagic fever dhf are acute febrile diseases transmitted by mosquitoes, which occur in the tropics. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Be sure to describe international trips in detail, including the countries you visited. Undifferentiated fevermay be the most common manifestation ofdengueprospective study found that 87% of patientsinfected were either asymptomatic or only mildlysymptomaticother prospective. Isolation of dengue virus from or demonstration of specific arboviral antigen or genomic sequences in tissue, blood, cerebrospinal fluid csf, or other body fluid by polymerase chain reaction pcr test, immunofluorescence or immunohistochemistry, or seroconversion from negative for dengue virusspecific serum immunoglobulin m igm antibody.