Lenalidomide, cyclophosphamide and weekly dexamethasone. If lenalidomide is used during pregnancy, it may cause birth defects or death to a developing baby. Lenalidomide maintenance therapy for multiple myeloma full. Call your doctor for medical advice about side effects. It promotes immune responses to help slow tumor growth. Lenalidomide in plasma bioequivalence based on 90% ci. Starting dose adjustment for renal impairment in mds. Aarps rx price watch report shows prescription drug costs rose at twice the. To test the longterm effectiveness of lenalidomide therapy for multiple myeloma. Lenalidomide is used to treat multiple myeloma bone marrow cancer, either in combination with. Embryofetal toxicity lenalidomide, a thalidomide analogue, caused limb abnormalities in. It is a thalidomide analogue, with improved potency and reduced toxicity compared with thalidomide. Apr 23, 2020 see full prescribing information for complete boxed warning. Revlimid lenalidomide dosing, indications, interactions.
In the donut hole also called the coverage gap stage, youll. Embryofetal toxicity lenalidomide, a thalidomide analogue, caused limb abnormalities in a developmental monkey study similar to birth defects caused by thalidomide in humans. See full prescribing information for complete boxed warning. Member benefits download pdf of benefits aarp auto buying. Jun 06, 2019 our revlimid lenalidomide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
The use of the information on this website does not create a physicianpatient relationship between cancer care ontario and you. The views expressed herein are for information, debate, and discussion, and do not necessarily. Lenalidomide side effects, dosage, interactions drugs. Embryofetal toxicity and venous and arterial thromboembolism. Highlights of prescribing information these highlights do not include all the information needed to use revlimid safely and effectively. Pdf database study of lenalidomide revlimid in germany. Lenalidomide is similar to thalidomide, an older cancer medicine that, although effective, was associated with serious side effects. Hundreds of prescription drugs are costlier in 2020 aarp. Lenalidomide revlimid is an immunomodulatory drug with multiple mechanisms of action against multiple myeloma. Dexamethasone should continue to be taken even if lenalidomide is held due to a dose limiting toxicity. Highlights of prescribing information these highlights do not include all the information needed to use pomalyst safely and effectively.
Specialty price trends for most widely used prescription drugs. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Highlights of prescribing information these highlights do not include all the information needed to use warnings and precautions revlimid safely and effectively. Lenalidomide, a thalidomide analogue, caused limb abnormalities in a developmental monkey study similar to birth defects caused by thalidomide in humans. Celgene prides itself on the development of innovative cancer therapies and autoimmune disease treatments. Lenalidomide, despite its known toxicities, has significantly improved the oncepoor prognosis and survival rates of mm. These highlights do not include all the information needed to use revlimid safely and effectively. Platelets count falls to prescribing information for complete boxed warning. Analytes to measure in appropriate biological fluid. For prescribers, please enter your user name and password to manage your patients through a celgene rems program. Embryofetal toxicity, hematologic toxicity, and venous and arterial thromboembolism. Nov 09, 2018 lenalidomide affects the immune system. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020. Practical guide to management of lenalidomiderelated rash in.
The exact mechanism through which lenalidomide stops the growth of cancer cells is not understood. Lenalidomide may cause a serious type of reaction called tumor lysis syndrome. Keep taking lenalidomide as you have been told by your doctor or other health care provider, even if you feel well. Accidental release measures contain spill and collect, as appropriate. Realworld analysis of celgene global drug safety database. Revlimid medicare coverage and copay details goodrx. Bc cancer protocol summary for therapy of relapsed multiple.
Revlimid lenalidomide capsules, for oral use initial us approval. Jun 06, 2019 to avoid embryofetal exposure to lenalidomide, revlimid is only available through a restricted distribution program, the revlimid rems program. Trends in retail prices of specialty prescription drugs. Lenalidomide in transfusiondependent lowrisk or intermediate1 risk myelodysplastic syndrome without the deletion 5q chromosomal abnormality. Hd lenalidomide has evidence of clinical activity as initial therapy for older aml patients, and further study of lenalidomide in aml and mds is warranted. Revlimid lenalidomide capsules, for oral use initial u. National institute for health and care excellence nice 07 april 2020. Fetal risk lenalidomide, a thalidomide analogue, caused limb abnormalities in a developmental monkey study similar to birth defects caused by thalidomide in humans. For further information on revlimid, please refer to the full prescribing information revlimid dose quantity directions 2. Aarp shows impact of skyrocketing drug prices with new data and. Feb 24, 2020 how is this medicine lenalidomide best taken. Revlimid lenalidomide capsules prescribing information. Up to eight 21day treatment cycles 24 weeks of initial treatment are recommended.
If you do not have an online account, select create user account to establish an account. As the nations fastestgrowing pharmacy program, prescription hope can obtain over 1,500 fdaapproved prescription medications from over 180 u. For more detail, see how lenalidomide works section below. Your doctor may give you a medicine to help prevent this. New use for lenalidomide in multiple myeloma national. Lenalidomide revlimid in combination with dexamethasone is recommended, within its licensed indication, as an option for the treatment of multiple myeloma only in patients who have received two or more prior therapies. Lenalidomide stimulates or regulates the bodys immune system to attack and kill cancer cells, reduces. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Lenalidomide 20 mg po qday on days 121 every 28 days up to 12 cycles. Revlimid should not be used to treat people who have chronic lymphocytic leukemia cll unless. Lenalidomide is very similar to thalidomide, a drug which has caused severe possibly fatal birth defects when used during pregnancy. If lenalidomide is used during pregnancy, it may cause birth defects or embryofetal death. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for revlimid lenalidomide.
Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or. In the typical copay stage, your deductible has been satisfied, and medicare pays the majority of your drug costs. On february 22, the food and drug administration fda approved a new use for the drug lenalidomide revlimid in treating patients with multiple myeloma under the new approval, patients with multiple myeloma can receive lenalidomide as maintenance therapy after receiving an autologous stem cell transplant for the disease, to help keep the cancer from coming back. Side effects of revlimid lenalidomide, warnings, uses. Revlimid lenalidomide prescribing and labeling information. In the eu and usa, lenalidomide monotherapy is indicated for the maintenance treatment of patients with newly diagnosed multiple myeloma who have undergone autologous stemcell.
In the deductible copay stage, you are responsible for the full cost of your prescriptions. Highlights of prescribing information these highlights do not include all the information needed to use thalomid safely and effectively. Lenalidomide is classified as an immunomodulatory agent and an antiangiogenic agent. Treatment of transfusiondependent myelodysplastic syndrome mds patients with deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities. Fetal risk, hematologic toxicity, and deep vein thombosis and pulmonary embolism. A drug list, or formulary, is a list of prescription drugs covered by your plan.
Revlimid lenalidomide is a prescription medicine, used to treat adults with multiple myeloma mm in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation a type of stem cell transplant that uses your own stem cells. Dosage modifications mds thrombocytopenia within 4 weeks at starting dose 10 mgday. Always consult your healthcare provider if you have questions or concerns. It will also look at the effects of extended treatment on the cancer and the immune system. Not mutagenic in ames test and mammalian in vitro mutation test. Pomalyst pomalidomide capsules, for oral use initial u. Fetal risk lenalidomide, a thalidomide analogue, caused limb. Lenalidomide revlimid is an oral anticancer medication.
Visit our product websites or download patient and prescribing information to learn more about lifechanging celgene products and services. Prescribing and technical information lenalidomide with rituximab for previously treated follicular lymphoma guidance ta627 source. Lenalidomide may potentiate the drowsiness caused by alcohol and other sedative medication. Platelets count falls to lenalidomide as firstline treatment for multiple myeloma was based on the first study, a phase 3, multicenter, randomized, openlabel, 3arm clinical trial that compared the efficacy and safety of lenalidomide plus dexamethasone versus mpt and versus lenalidomide given for 18 cycles in patients with newly diagnosed. Those prescribed revlimid may be able to access prescription medication with the help of prescription hope. Embryofetal toxicity, hematologic toxicity, and venous and arterial. This draft guidance, once finalized, will represent the food. Information about the revlimid rems program is available at. This is not a complete list of side effects and others may occur. The information on this website is intended for informational purposes only and is not a substitute for medical advice.
Aug 29, 2012 lenalidomide is a drug that may reduce or prevent the growth of cancer cells. In 2016, 28% of americans stopped taking a prescription drug as. Embryofetal toxicity, hematologic toxicity, and venous thromboembolism. Dose levels lenalidomide on days 121 of every 28day. Researchers want to look at the longterm effect of lenalidomide on immune cells. If lenalidomide is taken during pregnancy, it may also cause. Refer to prescribing information for rituximab for dosing.
It is recommended only if the manufacturer provides lenalidomide according to the commercial arrangement. Member benefits download pdf of benefits aarp auto buying program hot deals. Patients currently enrolled in a celgene rems program are not required to create an online account to complete a survey. Thalomid thalidomide capsules, for oral use initial u. For further information on revlimid, please refer to the full prescribing information tape prescription here prior to faxing referral, or complete the following.